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The pleiotropic effects of tobacco smoke on the immunostimulatory function of DCs are further illustrated by a study reporting a diminished capacity of DCs from cigarette smoke-exposed mice to induce IL-2 production by T cells, which was associated with a decreased antigen-specific T-cell proliferation in vivo

If skin or eyes have come in contact with nicotine, rinsing them with warm water for 15 minutes may help minimize burning

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While these cultural tobacco products can gain widespread acceptance, they rarely surpass cigarettes in overall use